About Gene Scale
The industry-Academia Alliance for Prevalent Disease
GENE-SCALE 2026 was founded on the principle that the "proof of concept" era for gene therapy is now behind us. As we navigate the realities of 2026, the global conversation has shifted from whether we can edit the human genome to how we can do so with surgical precision for millions of patients. This summit serves as the critical bridge between groundbreaking discovery and large-scale execution, dedicated to catalyzing the shift from treating rare, ultra-orphan conditions to addressing the world’s most prevalent chronic diseases, including cardiovascular failure, neurodegeneration, and metabolic disorders. We focus on the transition from lab-scale prototypes to modular, automated, and reimbursed therapies for millions.
Our mission is to dismantle the bottlenecks that prevent life-altering therapies from reaching the bedside. While discovery remains vital, the current landscape demands a relentless focus on the "Last Mile"—the complex intersection of AI-optimized manufacturing, scalable delivery platforms, and sustainable reimbursement models. GENE-SCALE 2026 brings together the architects of the new bio-economy: from the scientists engineering the next generation of non-viral vectors to the industrial leaders building the modular factories of the future. We provide the definitive forum where technical excellence meets regulatory harmony to ensure global patient access.
Speaker Application FormStep into the industrial era of genetic medicine at GENE-SCALE 2026. Beyond the laboratory, we are gathering the architects of scale—the visionaries bridging the gap between breakthrough science and global patient access. Join 500+ leaders in San Diego to master the complexities of precision editing, AI-driven manufacturing, and the commercial transition to prevalent diseases. The future isn't just taking shape; it’s being built here.
Gene Scale 2026 Speakers
Matthias Stephan
Professor, Translational Science and Therapeutics Division
Injectable bioinstructive microfoam for rapid bedside/in vivo
Why Attend Gene-Scale 2026
Gene-Scale 2026 offers a unique opportunity for professionals across various sectors to come together and participate in a transformative event focused on gene therapy. Here are several compelling reasons why individuals should attend:
Stay Updated on the Latest Advancements
Gene-Scale 2026 provides access to cutting-edge research and breakthrough technologies.
Networking and Collaboration
A platform for networking and collaboration among industry leaders, researchers, and other stakeholders.
Professional Development
Gain invaluable insights and skills through keynote presentations, discussions, and interactive sessions.
Access to Expertise
Engage with experts, thought leaders, and key opinion leaders in the gene therapy field.
Influence and Impact
Influence the direction of gene therapy advancements and policy shaping future developments.
Inspiration and Motivation
Be inspired by innovative research and patient success stories, fueling your own passion in the field.
Agenda at a Glance
Precision 2.0 – Beyond the Double-Strand Break
Base and Prime Editing clinical readouts for Hypercholesterolemia and Amyloidosis. How "search-and-replace" technology has eliminated off-target fears.
In-Vivo Delivery: The End of the Hospital Stay
High-impact talks on LNP-mediated In-Vivo CAR-T. Can we treat 100,000 patients by eliminating ex-vivo engineering?
The Neuro-Genomic Frontier: Crossing the BBB
New capsid engineering and non-viral ligands for Alzheimer’s and Parkinson’s—moving from "managing symptoms" to "genetic reversal."
Epigenetic Silencing: The Permanent Switch
Utilizing CRISPR-off technology for chronic pain and hypertension without altering the DNA sequence.
Fast-Track Innovation: Late-Breaking Data Flash
Rapid-fire 10-minute presentations on the most recent 2026 clinical results, designed to attract venture-backed startups and PIs.
The AI-Driven Digital Twin
Using AI to simulate thousands of batch runs in seconds to optimize yield. Moving from "Trial and Error" to "Predictive Bioprocessing."
Modular Manufacturing: The Rise of the 'Bio-Pod'
A technical look at Decentralized Manufacturing. Deploying small-footprint, automated "pods" directly in regional hospitals.
Real-Time Release: The 24-Hour Quality Goal
Integrating Automated Analytical Development (ddPCR/NGS) into the production line to eliminate the 3-week QC wait time.
Non-Viral Vectors: Scaling the Supply Chain
Addressing the 2026 bottleneck: Scaling plasmid and LNP production for millions of doses vs. the scarcity of viral vectors.
The CDMO Round-Table: Automation vs. Labor
A high-level debate on the role of robotics in replacing manual cleanroom labour to ensure 2026 cost-viability.
The Pay-for-Performance Model: 2026 Data
A review of multi-year annuity payments for curative therapies. How payers are handling the shift to Heart Failure populations.
Global Regulatory Convergence: One Filing, Many Markets
How the FDA and EMA are harmonizing CMC requirements for prevalent disease trials to speed up 2027 launches.
Closing Panel: From Niche to Necessity
CEOs from top Biotechs discuss the 5-year roadmap for Cardiovascular Gene Therapy—the industry's next $100B market.
The 2030 Genomic Landscape
Investment trends for the "post-rare" era. Where will the smart money flow in 2027?
Interested in Sponsoring Gene-Scale 2026?
If your company is interested in sponsoring Gene-Scale 2026, we would be delighted to discuss the opportunities with you. Please send us a quick email, and we will promptly provide you with more information and our sponsorship brochure.
Sponsors
Gene-Scale 2026: Advancing Innovation, Transforming Lives: The Future of Gene Therapy Starts Here
Venue
Hyatt Regency La Jolla at Aventine
3777 La Jolla Village Dr, San Diego, CA 92122
United States


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